Expression data from primary term human decidual cells treated with interleukin-1-beta for 6 hours.

Preterm birth is an important unsolved clinical problem. Despite advanced treatments, infants who survive prematurity remain at increased risk for permanent disabilities. In approximately one-third of cases, prematurity is related to infection and/or inflammation, which renders hostile the normally receptive intrauterine environment. Proinflammatory cytokines provoke up-regulation of genes that promote uterine contractions. Using monolayer cultures of human decidual cells as a model, we profiled the global pattern of gene expression in response to cytokine challenge.

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Ibrahim SA, Ackerman WE 4th, Summerfield TL, Lockwood CJ, Schatz F, Kniss DA