Decreased expression of cell proliferation-related genes in clonally derived skin fibroblasts from children with Silver-Russell syndrome is independent of the degree of 11p15 ICR1 hypomethylation

GSE61120

Homo sapiens

16 Downloadable Samples

Affymetrix Human Genome U219 Array (hgu219)

Submitter Supplied Information

Description

The in-vitro analysis of the hypomethylation of the imprinting control region 1 (ICR1) within the IGF2/H19 locus is challenged by the mosaic distribution of the epimutation in tissues from children with Silver-Russell syndrome (SRS).

PubMed ID

25657826

Publication Title

Decreased expression of cell proliferation-related genes in clonally derived skin fibroblasts from children with Silver-Russell syndrome is independent of the degree of 11p15 ICR1 hypomethylation.

Total Samples

Submitter’s Institution

DKFZ

Authors

Heckmann D, Urban C, Weber K, Kannenberg K, Binder G

Source Repository

Gene Expression Omnibus (GEO)

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