Stress response of Saccharomyces cerevisiae to exposure to natural product pyocyanin.

Pyocyanin has been shown to engage in redox transfer of electrons from NADPH to oxygen to generate superoxide radicals. Transcriptional response to oxygen stress has been characterized in yeast and should be observable upon exposure to pyocyanin if this is the true mode of action.

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Angell S, Bench BJ, Williams H, Watanabe CM