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Accession IconGSE62156

Gene expression signatures of 64 T-ALL patient diagnosis samples

Organism Icon Homo sapiens
Sample Icon 64 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description
Genetic studies have shown that human T-ALLs can be divided into subgroups that are characterized by unique gene expression signatures and relate to stages of T-cell differentiation at which the leukemic cells arrest. Each molecular subgroup has characteristic genetic abnormalities that cause aberrant activation of specific T-ALL transcription factor oncogenes, including LYL1/MEF2C, HOXA, TLX1, TLX3 and TAL1/LMO2. Notably, the recently described Early T-cell Precursor ALL (ETP-ALL) patients have leukemic cells that show an early block in T-cell differentiation and significantly overlap with LYL1-positive T-ALL and MEF2C-dysregulated immature T-ALL. We studied the gene expression profiles of 64 primary T-ALL samples and found a high BCL-2 expression in immature T-ALL patients compared to patients belonging to other subgroups.
PubMed ID
Total Samples
64
Submitter’s Institution

Samples

Show of 64 Total Samples
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Additional Metadata
JSR_001_U133_2
bone marrow
JSR_025_U133_2
blood
JSR_002_U133_2
blood
JSR_059_U133_2
bone marrow
JSR_074_U133_2
bone marrow
JSR_031_U133_2
bone marrow
JSR_118_U133_2
blood
JSR_080_U133_2
blood
JSR_041_U133_2
bone marrow
JSR_048_U133_2
bone marrow
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