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Accession IconGSE6253

A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer

Organism Icon Homo sapiens
Sample Icon 72 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U95A Array (hgu95a), Affymetrix Human Genome U133B Array (hgu133b), Affymetrix Human Genome U133A Array (hgu133a)

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We applied a meta-analysis of datasets from seven different microarray studies on lung cancer for differentially expressed genes related to survival time (under 2 y and over 5 y). Systematic bias adjustment in the datasets was performed by distance-weighted discrimination (DWD). We identified a gene expression signature consisting of 64 genes that is highly predictive of which stage I lung cancer patients may benefit from more aggressive therapy.
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