Human embryonic stem cell based neuro-developmental toxicity assay: response to valproic acid and carbamazepine exposure

GSE64123

Homo sapiens

90 Downloadable Samples

Affymetrix HT HG-U133+ PM Array Plate (hthgu133pluspm)

Submitter Supplied Information

Description

Here we studied the effects of anticonvulsant drug exposure in a human embryonic stem cell (hESC) based neuro- developmental toxicity test (hESTn). During neural differentiation the cells were exposed, for either 1 or 7 days, to non-cytotoxic concentration ranges of valproic acid (VPA) or carbamazepine (CBZ), anti-epileptic drugs known to cause neurodevelopmental toxicity.

PubMed ID

25979313

Publication Title

Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Total Samples

Submitter’s Institution

Natl. Inst. Public Health & Environment

Authors

Schulpen SH, Pennings JL, Piersma AH

Source Repository

Gene Expression Omnibus (GEO)

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