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Accession IconGSE65851

Beta Amyloid toxicity in a Caenorhabditis elegans model of Alzheimer's disease

Organism Icon Caenorhabditis elegans
Sample Icon 47 Downloadable Samples
Technology Badge Icon Affymetrix C. elegans Genome Array (celegans)

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Transgenic animals were engineered to express human amyloid peptide controlled by a muscle-specific, heat-inducible promoter. At low temperatures (16C) Abeta expression is minimal, while at higher temperatures (20-25C) Abeta accummulates in large quantities and causes paralysis.
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