github link
Accession IconGSE66468

Opposite phenotypic effects and genetic dosage in mouse models of 16p11.2 deletion and duplication syndromes

Organism Icon Mus musculus
Sample Icon 56 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Gene 2.1 ST Array (mogene21st)

Submitter Supplied Information

Description
The 16p11.2 deletion and duplication syndromes have been associated with developmental delay and autism spectrum disorders, and a reciprocal effect on body mass index. Here we explored these links with new engineered mouse models carrying a deletion (Del/+) and duplication (Dup/+) of the whole 16p11.2 homologous Sult1a1-Spn region. On a pure genetic background, compared to wild-types, Del/+ mice carrying the deletion showed weight and adipogenesis deficits, hyperactivity, repetitive behaviors, and recognition memory deficits, whereas Dup/+ mice showed the opposite phenotypes and Del/Dup individuals displayed no changes. Alterations in social interaction were also observed in Del/+ and Dup/+ animals on a mixed genetic background.
PubMed ID
Total Samples
56
Submitter’s Institution

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Specimen part
Processing Information
Additional Metadata
No rows found
Loading...