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Accession IconGSE68128

Chronic subacute (incl. one subchronic study) exposure of Wistar rats to (non-)carcinogenic compound

Organism Icon Rattus norvegicus
Sample Icon 119 Downloadable Samples
Technology Badge Icon Affymetrix Rat Gene 2.0 ST Array (ragene20st), Affymetrix Rat Expression 230A Array (rae230a)

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Description
The carcinogenic potential of chemicals is currently evaluated with rodent life-time bioassays, which are time consuming, and expensive with respect to cost, number of animals and amount of compound required. For insight into early mechanisms of non-genotoxoc carcinogenesis and for identification of potential early biomarkers of non-genotoxic carcinogenesis, groups of rats were treated with a range of known non-genotoxic carcinogens for a period of 14, 28, or 90 days, and liver tissue was harvested for expression profiling. Control groups were treated with appropriate vehicles.
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