Differential regulation of cerebral metabolic genes after hyperglycemic and normoglycemic cardiac arrest

Severe cerebral ischemia caused by events such as ischemic stroke or cardiac arrest is a relatively common and life-threating condition. Those who survive frequently suffer from significant cerebral dysfunction, often with poor outcome. To date the treatment options are limited. Concomitant hyperglycemia is frequently perceived both in focal and global transient ischemia, augmenting the ischemic brain injury as revealed by experimental and clinical studies.

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Lindblom RPF, Molnar M, Israelsson C, Röjsäter B, Wiklund L, Lennmyr F