Genome-wide analysis of microRNA-22 responsive gene expression in lung antigen presenting cells in response to chronic nanoparticulate carbon black exposure

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GSE72734

Mus musculus

12 Downloadable Samples

Illumina MouseWG-6 v2.0 expression beadchip

Submitter Supplied Information

Description

Analysis of lung CD11c+ antigen presenting cells (APCs) isolated from wildtype or Mir22-/- mice exposed to nanoparticulate carbon black (nCB) for one month. MiR-22 plays important roles in nCB induced experimental emphysema through regulating APC activation. Results provide insight into the biological role and target genes of miR-22.

PubMed ID

26437241

Publication Title

The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.

Total Samples

Submitter’s Institution

Baylor College of Medicine

Authors

Lu W, You R, Yuan X, Yang T, Samuel EL, Marcano DC, Sikkema WK, Tour JM, Rodriguez A, Kheradmand F, Corry DB

Source Repository

Gene Expression Omnibus (GEO)

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