Hematopoietic stem cell mobilization with G-CSF (gene expression profiling)

GSE7400

Homo sapiens

10 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated based on gene microarray analysis.

PubMed ID

17761290

Publication Title

Hematopoietic stem cell mobilization with G-CSF induces innate inflammation yet suppresses adaptive immune gene expression as revealed by microarray analysis.

Total Samples

Submitter’s Institution

University of South Florida College of Medicine

Authors

Buzzeo MP, Yang J, Casella G, Reddy V

Source Repository

Gene Expression Omnibus (GEO)