Genome wide analysis of placental malaria

Chronic inflammation during placental malaria (PM) caused by Plasmodium falciparum is most frequent in first-time mothers and is associated with poor maternal and fetal outcomes. In the first genome wide analysis of the local human response to sequestered malaria parasites, we identified genes associated with chronic PM, then localized the corresponding proteins and immune cell subsets in placental cryosections.

20

Muehlenbachs A, Fried M, Lachowitzer J, Mutabingwa TK, Duffy PE