Neuromedin U promotes a malignant phenotype in luminal breast cancer involving Naked 2 (NKD2) modulated WNT signalling

GSE75932

Homo sapiens

1 Downloadable Sample

Affymetrix Human Gene 2.0 ST Array (hugene20st)

Submitter Supplied Information

Description

Neuromedin U (NMU), which is thought to contribute to putative metastasis processes in various tumor entities, was identified as being up-regulated in breast cancer. Therefore, we aimed to uncover the role of NMU in breast cancer subtypes deciphering for the first time NMU-driven signalling pathways and downstream targets.

PubMed ID

28423716

Publication Title

Oncogenic features of neuromedin U in breast cancer are associated with NMUR2 expression involving crosstalk with members of the WNT signaling pathway.

Total Samples

Submitter’s Institution

RWTH Aachen University

Authors

Garczyk S, Klotz N, Szczepanski S, Denecke B, Antonopoulos W, von Stillfried S, Knüchel R, Rose M, Dahl E

Source Repository

Gene Expression Omnibus (GEO)

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