Overexpression of Crumbs3/CRB3 in human mammary epithelial line MCF-10A

GSE76610

Homo sapiens

6 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Our data demonstrate that overexpression of the polarity protein Crb3 elicits changes in MCF-10A cells that culminate in an increase in the release of amphiregulin (AR) and the subsequent activation of EGFR signaling to drive proliferation. Microarray analysis was performed to define global changes in the transcriptional landscape induced by Crb3. Results provide insight into a FERM domain protein (EBP41L4B) required for Crb3 mediated induction of proliferation.

PubMed ID

30440051

Publication Title

CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.

Total Samples

Submitter’s Institution

Harvard Medical School

Authors

Walker SJ, Selfors LM, Margolis BL, Brugge JS

Source Repository

Gene Expression Omnibus (GEO)

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