Expression analysis of WT and Zbtb4 -/- mouse primary fibroblasts

GSE77816

Mus musculus

10 Downloadable Samples

Affymetrix Mouse Gene 2.0 ST Array (mogene20st)

Submitter Supplied Information

Description

ZBTB4 is a mammalian transcription factor with Zinc fingers and a BTB/POZ domain, which can bind methylated CpGs, as well as certain unmethylated consensus sequences. ZBTB4 is frequently downregulated in human cancers, but it is unclear whether this is a cause or consequence of transformation. To investigate the role of ZBTB4 in normal and pathological conditions, we generated Zbtb4-/- mice

PubMed ID

27815388

Publication Title

Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Total Samples

Submitter’s Institution

CNRS-Universit Paris Diderot - Sorbonne Paris Cit

Authors

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA

Source Repository

Gene Expression Omnibus (GEO)

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