RIP4 inhibits STAT3 Signaling to sustain Lung Adencarcinoma Differentiation

GSE81154

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Gene 2.0 ST Array (mogene20st)

Submitter Supplied Information

Description

Evaluation of the role of RIP4 in lung adenocarcinoma revealed that RIP4 inhibits STAT3 signaling in vitro and in vivo. Repression of RIP4 enhanced STAT3 signaling activation in KRAS LSL/G12D/wt; p53flox/flox murine tumors. This promoted cancer dedifferentiation through ECM remodeling

PubMed ID

28574510

Publication Title

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation.

Total Samples

Submitter’s Institution

SIB Swiss Institute of Bioinformatics

Authors

Kopparam J, Chiffelle J, Angelino P, Piersigilli A, Zangger N, Delorenzi M, Meylan E

Source Repository

Gene Expression Omnibus (GEO)

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