Expression data from SHP specific siRNA or nonspecefic siRNA transfected rat astrocytes [extended study]

GSE82247

Rattus norvegicus

12 Downloadable Samples

Affymetrix Rat Gene 2.0 ST Array (ragene20st)

Submitter Supplied Information

Description

To clarify the effect of SHP in LXRs-mediated signaling pathway, we performed global gene expression analysis of SHP siRNA transfected- or control siRNA transfected- astrocytes after IFN- and LXRs agonist. Microarray analysis revealed that expression of several genes encoding inflammatory mediators were reversed in SHP siRNA transfected-astrocytes, when compared with control siRNA transfected-astrocytes.

PubMed ID

27485016

Publication Title

Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.

Total Samples

Submitter’s Institution

Ajou university, School of Medicine

Authors

Lee JH, Kim H, Park SJ, Woo JH, Joe EH, Jou I

Source Repository

Gene Expression Omnibus (GEO)

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