Gene Expression Network Analyses in Response to Air Pollution Exposures in the Trucking Industry

To investigate the cellular responses induced by air pollution exposures, we performed genome-wide gene expression microarray analysis using whole blood RNA sampled at three time-points across the work weeks of 63 non-smoking employees in the trucking industry. Our objective was to identify the genes and gene networks differentially activated in response to micro-environmental measures of occupational exposure to three pollutants: PM2.5 (particulate matter 2.5 microns in diameter) and elemental carbon (EC) and organic carbon (OC).

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Chu JH, Hart JE, Chhabra D, Garshick E, Raby BA, Laden F