Transcriptomic analysis of monocyte to macrophage differentiation in the colon

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GSE84764

Mus musculus

12 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

Intestinal macrophages rely on the constant replenishment by bone marrow derived Ly6Chigh monocytes in the adult organism. The developmental path from monocytes towards intestinal macrophages locally in the tissue is defined by the loss of Ly6C and acquisition of MHCII and CX3CR1 expression. We used microarray analysis to further characterise this local differentiation process.

PubMed ID

28145440

Publication Title

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling.

Total Samples

Submitter’s Institution

University of Edinburgh

Authors

Schridde A, Bain CC, Mayer JU, Montgomery J, Pollet E, Denecke B, Milling SWF, Jenkins SJ, Dalod M, Henri S, Malissen B, Pabst O, Mcl Mowat A

Source Repository

Gene Expression Omnibus (GEO)

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