Effect of loss of CREB and CREM on kainate-induced gene expression in the hippocampus (MG-U74C).

Ablation of the Creb1 gene in forebrain neurons was performed using the Cre/loxP system, with the recombinase expressed from the Camk2alfa promoter. Mice were crossed into the Crem KO background to prevent compensation of CREB loss by CREM overexpression.

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Lemberger T, Parkitna JR, Chai M, Schütz G, Engblom D