Expression data from intestinal crypts and stroma of wild type and late generation (4th generation) telomerase-deficient mice

Telomeres shorten with each round of cell division, and the expression of telomerase serves to lengthen telomeres. In the absence of telomerase, telomeres shorten to the point of uncapping and causes defects in tissues with high turnover, including the intestinal epithelium. In mice lacking telomerase (e.g. mTR-/-), telomeres critically shorten after several generations of telomerase deficiency, with pronounced defects in their intestine.

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Yang TB, Chen Q, Deng JT, Jagannathan G, Tobias JW, Schultz DC, Wang S, Lengner CJ, Rustgi AK, Lynch JP, Johnson FB