Calcium-mediated shaping of naive CD4 T cell phenotype and function

Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their ability to differentiate into induced regulatory T cells. To decipher the molecular mechanisms governing this process, microarray data comparing highly (Ly-6C-) and lowly (Ly-6C+) Self-reactive naive CD4 T cells were obtained.

6

Guichard V, Bonilla N, Durand A, Audemard-Verger A, Guilbert T, Martin B, Lucas B, Auffray C