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Accession IconSRP022133

Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices

Organism Icon Homo sapiens
Sample Icon 25 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls. Overall design: Examination of the effect of LVAD implant on peripheral blood transcriptome. Blood was drawn before LVAD placement, 7 days post implant, and 180 days post implant. RNA sequencing was performaed on all samples.
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25
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