RNA-Seq Identifies Novel Myocardial Gene Expression Signatures of Heart Failure [RNA-seq]

We have utilized the RNA-Seq technology to identify genes with distinct expression patterns between failing and non-failing hearts. In an era of next-generation sequencing studies, our study demonstrates how knowledge gained from a small set of samples with accurately measured gene expressions using RNA-Seq can be leveraged as a complementary strategy to discern the genetics of complex disorders. Overall design: Identify the signature genes based on RNA-seq come from six Heart Failure and healthy individuals. Validation is based on Affymetrix microarray of a total of 313 individuals with/without Heart Failure.

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Jia C, Guan W, Yang A, Xiao R, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M, Li C