The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers

Build and Download Custom Datasets

refine.bio helps you build ready-to-use datasets with normalized transcriptome data from all of the world’s genetic databases.

SRP043078

Homo sapiens

6 Downloadable Samples

Illumina HiSeq 2000

Submitter Supplied Information

Description

Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. Overall design: RNAseq was performed in endogenous BCL6-depleted OCI-LY1 cells rescued with either WT or RD mutant BCL6 (N=3 for each group).

PubMed ID

25176650

Publication Title

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.

Total Samples

Submitter’s Institution

No associated institution

Authors

Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A

Source Repository

Sequence Read Archive (SRA)

No rows found