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Accession IconSRP045579

Genome-wide mapping of promoter-enhancer interactions with HiCap [RNA-seq]

Organism Icon Mus musculus
Sample Icon 1 Downloadable Sample
Technology Badge IconIllumina Genome Analyzer II

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Description
Although the locations of promoters and enhancers have been identified in several cell types, we have yet limited information on their connectivity. We developed HiCap, which combines Hi-C with promoter sequence capture, to enable genome-wide identification of regulatory interactions with single-enhancer resolution. HiCap analyses of mouse embryonic stem cells (mESC) identified promoter-enhancer interactions predictive of gene expression change upon perturbation, opening up for genomic analyses of long-range gene regulation. Overall design: HiCap was designed by combining Hi-C with with sequence capture (for all promoters) and carried out in mouse embryonic stem cells (mESC)
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