RNA-seq of human fibroblasts during replicative senescence

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SRP050179

Homo sapiens

45 Downloadable Samples

Illumina HiSeq 2000

Submitter Supplied Information

Description

Senescent human fibroblasts were compared to young proliferating fibroblasts. Five different cell lines were compared. Illumina sequencing (HiSeq2000) was applied to generate 50bp single-end reads. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de) Overall design: 48 samples: 3 biological replicates for each group: young proliferating and senescent BJ cells; young proliferating and senescent Wi-38 cells; young proliferating and senescent IMR-90 cells; 5 population doubling from young proliferating to senescent cell for HFF and MRC-5 cells

PubMed ID

27140416

Publication Title

Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.

Total Samples

Submitter’s Institution

No associated institution

Authors

Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, Hemmerich P

Source Repository

Sequence Read Archive (SRA)

No rows found