Next Generation Sequencing Comparison of C57BL/6J and BC027072 -/- Eye Transcriptomes

We report the single base pair analysis of the ocular transcriptome from wild type and BC027072 knockout animals. Comparison was analyzed to understand gene expression changes in a mouse model for early onset retinal degeneration which phenocopies a human form of autosomal recessive retinitis pigmentosa Overall design: Eye mRNA profiles were generated from 3 week-old C57BL/6J and BC027072 -/- in triplicate and sequenced using the Illumina HiSeq 2500

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Kevany BM, Zhang N, Jastrzebska B, Palczewski K