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Accession IconSRP055425

Intrinsic age-dependent changes and cell-cell contacts regulate nephron progenitor lifespan

Organism Icon Mus musculus
Sample Icon 77 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
Purpose: To use single-cell RNA-Seq analysis of nephron progenitors in order to determine transcrptional differences as nephron progenitors age. Methods: Using a combination of FACS sorting and a Fluidigm Single-cell auto-prep system, we generated high-throughput RNA-SEQ data of nephron progenitors during development Results: Single cells transcriptome profiling of nephron progenitors revealed progressive age-dependent changes with heterogeneity increasing in older populations. Overall design: 96-single cell transcriptomes were determined from nephron progenitors of e14.5, e18.5 and P0 using Cited1GFP transgenic animals
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91
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