github link
Accession IconSRP059674

MLX transcriptional regulation in muscle cells

Organism Icon Mus musculus
Sample Icon 15 Downloadable Samples
Technology Badge IconIllumina Genome Analyzer

Submitter Supplied Information

Description
This study set out to identify MLX transcriptional targets in muscle cells. C2C12 Myoblasts were virally transduced to increase MLX activity, by overexpression of the wild-type protein; and to decrease MLX activity by overexpression of a dominant negative MLX protein and by shRNA induced knockdown of MLX. Transcripts that were significantly and consistently regulated by the different modes of MLX modulation were identified. The largest proportion of these were genes encoding secreted proteins including growth factors, cytokines and extracellular proteins. We therefore conclude that MLX can regulate myokine transcripts. Overall design: mRNA profiles from C2C12 muscle cells with increased and decreased MLX activity were examined.
PubMed ID
Total Samples
15
Submitter’s Institution
No associated institution

Samples

Show of 15 Total Samples
Filter
Add/Remove
Accession Code
Title
Processing Information
Additional Metadata
MLX SHRNA_1
NA
MLX WT_2
NA
MLX WT_3
NA
MLX SHRNA_2
NA
MLX DN_1
NA
MLX DN_3
NA
MLX DN_2
NA
NT shRNA_1
NA
MLX WT_1
NA
MCS_1
NA
Loading...