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Accession IconSRP064923

Reduced insulin production relieves endoplasmic reticulum stress and induces beta-cell proliferation

Organism Icon Mus musculus
Sample Icon 16 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
We define the effects of reduced insulin production in beta-cells from tamoxifen-treated Ins1-/-:Ins2f/f:Pdx1CreERT:mTmG mice studied at a time point when insulin production was reduced by ~50%. Overall design: Examination of the transcriptome of adult pancreatic islets from mice with acute Ins2 gene knockout out on an Ins1 null background
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16
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