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Accession IconSRP065542

RNA-seq analysis of IMQ-treated wt and Trex2-/- skin

Organism Icon Mus musculus
Sample Icon 11 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
TREX2 is a keratinocyte specific 3’-deoxyribonuclease that participates in the maintenance of skin homeostasis upon damage. This transcriptome analysis identified multiple genes and pathways deregulated by TREX2 loss in the IMQ-induced psoriasis-like model in mouse skin. Overall design: mRNA sequencing of 5 biological replicates of skin from wild-type mice treated with Imiquimod and 6 of Trex2 knockout mice treated with Imiquimod
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11
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