Differential expression of RNAs in E9 tuft rostrums with NTDs

SRP066177

Mus musculus

3 Downloadable Samples

Ion Torrent Proton

Submitter Supplied Information

Description

Purpose: Identify genes and pathways affected in tuft embryos with NTDs Results: Expression of genes associated with neural tube closure and components of non-canonical WNT signaling/PCP pathways were affected Conclusions: TET1 regulates genes associated with neural tube closure Overall design: RNA pooled from the rostrums of E9 (18-22 somites) tuft/tuft embryos with NTD compared with respective wildtype background strain

PubMed ID

26989192

Publication Title

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

Total Samples

Submitter’s Institution

No associated institution

Authors

Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S

Source Repository

Sequence Read Archive (SRA)

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