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Accession IconSRP071085

Single cell transcriptome analysis of mouse thoracic sympathetic ganglia

Organism Icon Mus musculus
Sample Icon 302 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
We explore the heterogeneity of mouse thoracic ganglia demonstrating the presence of an unexpected variety of cell-types and identify specialized populations of nipple- and pilo-erector muscle neurons. These neurons extend axonal projections and are born amongst other neurons during embryogenesis, but remain unspecialized until target organogenesis occurs postnatally. Target innervation and cell-type specification is coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles. Overall design: RNA-seq analysis of 298 single sympathetic neuronal cells from the mouse thoracic ganglion
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321
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