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Accession IconSRP073183

Analysis of Post-TBI Gene Expression Signature Reveals Tubulins, NFE2L2, NFkB, CD44, and S100A4 as Treatment Targets for Traumatic Brain Injury

Organism Icon Rattus norvegicus
Sample Icon 30 Downloadable Samples
Technology Badge IconIllumina Genome Analyzer IIx, Illumina HiSeq 2000

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Description
TBI was induced with lateral fluid-percussion injury in adult male rats. Genome-wide RNA-seq of the perilesional cortex, ipsilateral thalamus and dorsal hippocampus was performed at 3 months post-TBI. The data highlighted chronic transcriptional changes, particularly, in the perilesional cortex and thalamus. Genes showing a significantly altered expression both in the cortex and thalamus were submitted to the LINCS web query to identify novel pharmacotherapies to improve post-TBI outcome. Overall design: TBI was induced to 5 rats, 5 sham operated served as a controls.
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30
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