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Accession IconSRP073294

Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation [RNA-seq]

Organism Icon Mus musculus
Sample Icon 33 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
We report that in developing B cells individual enhancers of Igk make up super-enhancer cluster where contacts between its components rely on all constituents. Reduction of interaction frequency in enhancer knock-out cells is associated with deminished transcriptional output of enhancers and Igk locus. Moreover, we find that Igk enhancer MiEk has an effect on levels of CBFb enrichment on Tcrb enhancer, Eb afffecting Tcrb recombination and T cell development. Overall design: Examination of expression, chromatin accessibility, histone modifications and nuclear organization in developing wild-type and Igk and Tcrb enhancer deficient B and T lymphocytes.
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35
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No associated institution

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