Assessing the impact of loss of ATF7IP and SETDB1 on the transcriptome

By comparing HeLa cells lacking ATF7IP or SETDB1 generated through CRISPR/Cas9-mediated gene disruption to wild-type HeLa cells, the goal of the experiment was to determine the effect of loss of the SETDB1•ATF7IP complex on the transcriptome. Overall design: Total RNA-seq of three independent knockout HeLa clones lacking either ATF7IP or SETDB1

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Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ