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Accession IconSRP099453

RNA-sequencing of murine norovirus (MNV) infection and loxoribine (Lox) stimulation in RAW264.7 macrophages

Organism Icon Mus musculus
Sample Icon 48 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
This study aimed to generate a comprehensive analysis of changes in the transcriptome following MNV infection. Furthermore, we aimed to perform a differential gene expression analysis between MNV infection and loxoribine (tlr7 agonist) treatment to delineate features of the host modified directly by the MNV as opposed to indirect changes induced through IFN signalling. Overall design: Transcript expression profiles of RAW264.7 cells mock infected, infected with MNV (MOI 5) or treated with loxoribine (1 mM) for 12 hrs were generated using Illumina NextSeq500.
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48
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