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Accession IconSRP107229

Adult CNS Myelin Enhances Axonal Outgrowth From Neural Stem Cells

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
The growth of neural stem cells is strongly enhanced on myelin in vitro and in vivo. To identify the mechanisms associated with this phenome, we compared RNA expression from mouse E12 derived spinal cord cells on stimulation substrates (laminin and myelin) to permissive substrates (PDL). We identified Negr1 as mediator of the stimulatory effects of myelin. Overall design: Examination of transcripts in embryonic spinal cord cells stimulated by laminin and myelin substrates in vitro.
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12
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