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Accession IconSRP119248

Clonally expanded CD4+ T cells with a unique gene signature contribute to persistence of the HIV-1 latent reservoir

Organism Icon Homo sapiens
Sample Icon 228 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
Surface expression of the viral Envelope protein (Env) was used to enrich reactivated latent T cells producing HIV-RNA, and single cell RNASeq was performed to study gene expression differences between latent cells and controls. Overall design: Latent CD4+ T cells from virologically suppressed patients were reactivated in vitro and isolated using antibodies against HIV-1 Env. Single cell RNASeq was performed comparing reactivated latent cells with control, unpurified cells from the same donor and with cells actively infected in vitro using HIV-1(YU2).
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228
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No associated institution

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