Impact of cecal ligation and puncture (CLP) on splenic NK1.1+CD3- gene expression [RNA-seq]

SRP148610

Mus musculus

6 Downloadable Samples

Illumina HiSeq 2000

Submitter Supplied Information

Description

NK cell transcriptome comparison of Day 2 Sham and Days 1,2 CLP Overall design: Mice underwent either Sham (control) or cecal ligation and puncture (CLP) surgery. Splenic NK cells (NK1.1+CD3-) were sorted from Sham hosts 2 days after surgery and from CLP hosts 1 and 2 days after surgery. Sorted cells were used for RNAseq analysis

PubMed ID

30379932

Publication Title

Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.

Total Samples

Submitter’s Institution

No associated institution

Authors

Jensen IJ, Winborn CS, Fosdick MG, Shao P, Tremblay MM, Shan Q, Tripathy SK, Snyder CM, Xue HH, Griffith TS, Houtman JC, Badovinac VP

Source Repository

Sequence Read Archive (SRA)

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