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Accession IconSRP156583

Transcriptome profiles of B cell subsets from healthy and SLE subjects

Organism Icon Homo sapiens
Sample Icon 266 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
SLE is characterized by the production of autoantibodies that arise from the B cell lineage. Therefore, we sought to assess the epigenetic and transcriptome profiles of distinct B cell subsets known to be expanded in SLE from healthy and SLE subjects. These data define the differentiation heirarchy of B cell subsets and the epigenetic and transcriptional consequences of SLE on human B cells. Overall design: Five distinct B cell subsets were FACS isolated from a cohort of SLE and HC subjects. For a subset of subjects, circulating Antibody Secreting Cells (ASC) were also isolated for comparisons. Cells were FACS sorted into lysis buffer and RNA purified and transcriptome profiles determined by RNA-seq.
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267
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