Arabidopsis plants were treated either with mock or MSB (0.2 mM of Menadione sodium bisulphite). <br></br>Tissue was sampled after 3, 6 and 24 hours.
Molecular analysis of menadione-induced resistance against biotic stress in Arabidopsis.
Age, Specimen part, Compound, Time
View SamplesNeurodegenerative brain disorders become more common in the aged. Most of these disorders are associated with or caused by selective death of certain neuronal subpopulations. The mechanisms underlying the differential vulnerability of certain neuronal populations are still largely unexplored and few neuroprotective treatments are available to date. Elucidation of these mechanisms may lead to a greater understanding of the pathogenesis and treatment of neurodegenerative diseases. Moreover, preconditioning by a short seizure confers neuroprotection following a subsequent prolonged seizure. Our goal is to identify pathways that confer vulnerability and resistance to neurotoxic conditions by comparing the basal and preconditioned gene expression profiles of three differentially vulnerable hippocampal neuron populations.
Gene expression changes after seizure preconditioning in the three major hippocampal cell layers.
No sample metadata fields
View SamplesPlant reproduction depends on the concerted activation of many genes to assure the correct communication between pollen and pistil. Here we queried the whole transcriptome of Arabidopsis thaliana in order to identify genes with specific reproductive functions.
Whole genome analysis of gene expression reveals coordinated activation of signaling and metabolic pathways during pollen-pistil interactions in Arabidopsis.
Specimen part
View SamplesDespite their different origin and function, both pollen tubes and root hairs share the same sort of apical growth mechanism, i.e., the spatially focused cell expansion at the very apex. Ion fluxes, membrane trafficking, the actin cytoskeleton and their interconnection via signaling networks have been identified as fundamental processes underlying this kind of growth. Several molecules involved in apical growth have been identified, but the genetic basis is far from being fully characterized. We have used Affymetrix Arabidopsis ATH1 GeneChips to obtain the expression profiles of isolated Arabidopsis root hairs. A comparison with the expression profile of flow-sorted pollen grains reveals an overlap in the expression of 4989 genes, which corresponds to 42% of the root hair transcriptome and 76% of the pollen transcriptome, respectively. Our comparison with transcriptional profiles of vegetative tissues by principal component analysis and hierarchical clustering shows a clear separation of these samples comprised of cell types with diffuse growth from the two cell types with apical growth. 277 genes are enriched and 49 selectively expressed, respectively, in root hairs and pollen. From this set of genes emerges an apical growth signature containing novel candidate genes for apical growth determination.
Transcriptional profiling of Arabidopsis root hairs and pollen defines an apical cell growth signature.
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Budding yeast Wapl controls sister chromatid cohesion maintenance and chromosome condensation.
No sample metadata fields
View SamplesCohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following its establishment in S-phase and its role in chromosome condensation.
Budding yeast Wapl controls sister chromatid cohesion maintenance and chromosome condensation.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.
Specimen part
View SamplesExpression data from pancreatic cancer cell lines and non-neoplastic pancreatic cell line HPDE
Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins.
Sex, Specimen part, Disease, Cell line
View SamplesGene expression analysis of pancreatic cancer associated fibroblasts and control fibroblasts
Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.
Specimen part, Disease
View SamplesUtilizing Affymetrix ATH1 microarrays to analyze transposon expression in DNA methylation mutants, and RNAi mutants, compared to wildtype.
miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.
Specimen part
View Samples