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accession-icon GSE19771
Neonat cardiomyocytes_hypertrophy_HDAC4
  • organism-icon Rattus norvegicus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Gene 1.0 ST Array (ragene10st)

Description

In order to identify targets for HDAC4, NRVM were infected with adenoviral vectors encoding beta-Galactosidase or Flag- HDAC4, and incubated in serum free or 10% fetal calf serum containing growth medium for 48 hrs.

Publication Title

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE47185
In silico nano-dissection: defining cell type specificity at transcriptional level in human disease
  • organism-icon Homo sapiens
  • sample-icon 220 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Defining cell-type specificity at the transcriptional level in human disease.

Sample Metadata Fields

Specimen part, Disease

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accession-icon GSE47183
In silico nano-dissection: defining cell type specificity at transcriptional level in human disease (glomeruli)
  • organism-icon Homo sapiens
  • sample-icon 114 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

To identify genes with cell-lineage-specific expression not accessible by experimental micro-dissection, we developed a genome-scale iterative method, in-silico nano-dissection, which leverages high-throughput functional-genomics data from tissue homogenates using a machine-learning framework.

Publication Title

Defining cell-type specificity at the transcriptional level in human disease.

Sample Metadata Fields

Specimen part, Disease

View Samples
accession-icon GSE47184
In silico nano-dissection: defining cell type specificity at transcriptional level in human disease (tubulointerstitium)
  • organism-icon Homo sapiens
  • sample-icon 106 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

To identify genes with cell-lineage-specific expression not accessible by experimental micro-dissection, we developed a genome-scale iterative method, in-silico nano-dissection, which leverages high-throughput functional-genomics data from tissue homogenates using a machine-learning framework.

Publication Title

Defining cell-type specificity at the transcriptional level in human disease.

Sample Metadata Fields

Specimen part, Disease

View Samples
accession-icon E-MEXP-432
Transcription profiling of inducible overexpression of Arabidopsis meristem regulators by AlcR / AlcA system in continuous light
  • organism-icon Arabidopsis thaliana
  • sample-icon 10 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

Inducible overexpression of Arabidopsis meristem regulators by AlcR / AlcA system. Plants harboring 35S::AlcR/AlcA::GOI (GUS control, LEAFY, SHOOTMERSTEMLESS, WUSCHEL)constructs were grown in continous light for 12 days and induced with 1% Ethanol. After 12h of EtOH treatment, seedlings were dissected and RNA was processed from the shoot apex and young leaves. Affymetrix Ath1 arrays were hybridized in duplicates from each experiment.

Publication Title

WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulators.

Sample Metadata Fields

Age, Specimen part, Subject, Compound

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accession-icon GSE1907
Sarcoidosis + Follow-up study
  • organism-icon Homo sapiens
  • sample-icon 32 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U95A Array (hgu95a)

Description

Sarcoidosis + Follow-up 6 month after

Publication Title

Functional genomics and prognosis in sarcoidosis--the critical role of antigen presentation.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE14051
Expression signatures and cytogenetic aberrations in HPV16 E6, E7 and E6/E7-positive immortalized human epithelial cells
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Identification of genetic/cytogenetic alterations and differentially expressed cellular genes in HPV16 E6, E7 and E6/E7 positive human foreskin keratinocytes

Publication Title

Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE14052
Differentially expressed cellular genes in non-tumorigenic and tumorigenic HPV18 positive HeLa x fibroblast hybrid cells
  • organism-icon Homo sapiens
  • sample-icon 3 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Identification of genes differentially expressed in tumorigenic compared to non-tumorigenic, HPV18 positive cells

Publication Title

Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon SRP043188
HeLa cell polyA- RNA-seq
  • organism-icon Homo sapiens
  • sample-icon 1 Downloadable Sample
  • Technology Badge IconIlluminaHiSeq2000

Description

Coilin iCLIP data revealed 42 novel human snoRNAs of intronic origin. To validate their expression and estimate abundance of novel and annotated snoRNAs, we performed RNA-seq on polyA- and rRNA-depleted RNA isolated from HeLa cells. Results show that expression of novel snoRNAs is comparable to the previously annotated snoRNAs. Overall design: 1 replicate of RNA depleted of polyA and ribosomal RNA.

Publication Title

The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE9493
Transcriptomic analyses of renal allograft biopsies reveal conserved rejection signatures and molecular pathways
  • organism-icon Homo sapiens
  • sample-icon 80 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the subseries listed below.

Publication Title

Analysis of independent microarray datasets of renal biopsies identifies a robust transcript signature of acute allograft rejection.

Sample Metadata Fields

Sex, Age, Subject

View Samples

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

Powered by Alex's Lemonade Stand Foundation

Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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