The same entry pathway is shared by HBV and HDV. Both viruses attach to hepatocytes via heparansulfate proteoglycan and utilize sodium taurocholate co-transporting polypeptide (NTCP) for a specifc entry. This specific entry step is inhibited by Myrcludex B, a 47-aa lipopeptide myristoylated at the N-terminus. Here we compared the cellular response in the gene expression level triggerred by both viruses. The microarray data shows that HBV infection leads to a silent response but HDV infection triggers high level of innate response such as inteferon-stimulated genes (ISG) expression. Moreover, the response depends on the hepatic cell lines used for infection. Compared to HepG2 cells, HuH7 can not induce ISG even infected by HDV.
Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.
Cell line, Time
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Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.
Sex, Age, Specimen part, Cell line, Treatment
View SamplesGene expression profiling of NSCLC tumors with distinct PAEP expression suggested several pathways, which might be involved in the regulation of PAEP/glycodelin expression.
Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.
Sex, Age, Specimen part
View SamplesNon-small cell lung cancer (NSCLC) can be classified into the major subtypes adenocarcinoma (AC) and squamous cell carcinoma (SCC) subtypes. Although explicit molecular, histological and clinical characteristics have been reported for both subtypes, no specific therapy exists so far. However, the characterization of suitable molecular targets holds great promises to develop novel therapies in NSCLC. In the present study, global gene expression profiling of 58 human high grade NSCLC specimens revealed large transcriptomic differences between AC and SCC subtypes: More than 1.700 genes were found to be differentially expressed.
Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes.
Disease, Disease stage
View SamplesWe compared H1975 and 2106T cells treated with PAEP/glycodelin expression inducing substances and the corresponding contol treated cells.
Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.
Specimen part, Cell line, Treatment
View SamplesTo identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 knock down experiments followed by RNA-Seq analyses. By integration of both gene lists we identified top candidate genes regulated by BRD4. Overall design: HEK cells have been investigated for genomewide BRD4 binding sites and expression changes after knock down of BRD4. Illumina sequencing was used to gather data of the type ChIP Seq and mRNA Seq.
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid.
Specimen part, Disease, Disease stage, Subject
View SamplesWe investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or benign diagnosis.
Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid.
Specimen part, Disease, Disease stage, Subject
View SamplesDilated cardiomyopathy (DCM) is a common cause of heart failure and a leading cause of cardiac transplantation in western countries. The robust predictive expression profile of cardiomyopathic and NF hearts as well as the functional classification can help to identify promising candidates for DCM and may improve the early diagnosis of cardiomyopathy.
Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies.
No sample metadata fields
View SamplesCell lines play an important role for studying tumor biology and novel therapeutic agents. We demonstrated that cell lines represent a useful and reliable in vitro system for studying basic mechanisms in lung cancer. Moreover, we presented 3 novel, comprehensively characterized SCC cell lines.
Establishment and comparative characterization of novel squamous cell non-small cell lung cancer cell lines and their corresponding tumor tissue.
Specimen part, Disease, Cell line
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