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GSE44181
Mus musculus
51 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
Hematopoietic stem/progenitor cells (HSPCs) are at the basis of the hematopoietic hierarchy. Their ability to self-renew and differentiate is strictly controlled by molecular signals produced by their surrounding micorenvironments composed of stromal cells. HSPCs first emerge in the AGM (Aorta Gonads Mesonephros) region, amplify in the fetal liver (FL) and are maintained in the adult bone marrow (BM). To further characterize the molecular program of the HSPC niches, we have compared the global transcriptome of HSPC-supportive and non/less-supportive stromal clones established from the AGM, FL and BM.
Publication Title
A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.
Sample Metadata Fields
Specimen part
View Samples- Mus musculus
- 6 Downloadable Samples
- Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
comparative expression between stromal MS5 cells treated with (MS5_PD18) or without (MS5_DMSO) MEKi
Publication Title
Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.
Sample Metadata Fields
Cell line
View Samples