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GSE45630
Homo sapiens
180 Downloadable Samples
Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
To understand the molecular curcuits perturbed by BET bromodoman inhibtion we obtained gene expression profiling of five DLBCL cell lines, SU-DHL6, OCI-Ly1, OCI-Ly4, Toledo and HBL-1, which were treated with either 500nM JQ1 or DMSO for 0,2,6,12,24 and 48hr.
Publication Title
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.
Sample Metadata Fields
Specimen part, Cell line, Treatment, Time
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
Given that the NF-B pathway plays an important role in tumor development and that IKK2 is the seminal kinase responsible for NF-B pathway activation, we were particularly interested in exploring the therapeutic potential of IKK2 inhibition in non-small cell lung cancers.
Publication Title
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model.
Sample Metadata Fields
Specimen part
View Samples- Homo sapiens
- 31 Downloadable Samples
- Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degrees
Publication Title
Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.
Sample Metadata Fields
Sex, Age, Specimen part, Disease, Disease stage
View Samples