Multiple myeloma (MM) is a clonal plasma cell disorder frequently accompanied by hematopoietic impairment. Genomic profiling of distinct HSPC subsets revealed a consistent deregulation of signaling cascades, including TGF beta signaling, p38MAPK signaling and pathways involved in cytoskeletal organization, migration, adhesion and cell cycle regulation in MM patients.
Multiple myeloma-related deregulation of bone marrow-derived CD34(+) hematopoietic stem and progenitor cells.
Specimen part, Disease, Disease stage
View SamplesSpontaneous neural repair from endogenous neural stem cells (NSCs) occurs in response to central nervous system (CNS) injuries or diseases to only a limited extent from endogenous NSCs niches. Uncovering the mechanisms that control neural repair and can be further manipulated to promote towards oligodendrocyte progenitors cells (OPCs) and myelinating oligodendrocytes is a major objective.
Prickle1 as positive regulator of oligodendrocyte differentiation.
Sex, Age, Specimen part, Time
View SamplesChildren with acute measles were admitted to the University Teaching Hospital in Lusaka, Zambia. Peripheral blood was collected at hospital entry, discharge and 1-month follow-up. Control samples were also collected from uninfected children. All children were HIV negative.
Gene expression changes in peripheral blood mononuclear cells during measles virus infection.
No sample metadata fields
View SamplesHuman CD14+ monocytes were isolated and grown in GM-CSF and IL-4 for six days. The cells were then infected with measles virus, Chicago-1 strain, and RNA was isolated at 3, 6, 12, and 24 hours post-infection.
Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes.
Treatment
View SamplesWe used yeast RNA to estimate background binding for each probe on the human U133 plus 2.0 array.
The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes.
Treatment
View SamplesWe hybridized yeast RNA to the mouse 430 2.0 array to estimate the background binding for each probe.
The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes.
Treatment
View SamplesThis SuperSeries is composed of the SubSeries listed below.
MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Specimen part, Time
View SamplesCampare the difference between pairwise NOF and coCAF tissues for three patients
MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Specimen part, Time
View SamplesA doxycycline-inducible system was used to induce PU.1 expression in cultured myeloid cell lines. The parent cell line used was BN (Kamath et al., Leukemia 22:1214-1225, 2008).
PU.1 promotes cell cycle exit in the murine myeloid lineage associated with downregulation of E2F1.
Specimen part, Treatment
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