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accession-icon GSE29246
RAP1A signaling in Leishmania donovani infected macrophages
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Monastrol treatment of Leishmania donovani infected macrophages

Publication Title

A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol.

Sample Metadata Fields

Specimen part, Disease, Treatment

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accession-icon GSE68731
Expression analysis of RPA12 in Saccharomyces cerevisiae (BY4741)
  • organism-icon Saccharomyces cerevisiae
  • sample-icon 3 Downloadable Samples
  • Technology Badge Icon Affymetrix Yeast Genome 2.0 Array (yeast2)

Description

RPA12 is a subunit of RNA polymerase I.

Publication Title

Microarray data analyses of yeast RNA Pol I subunit RPA12 deletion strain.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE22535
Expression data from mouse liver on multisetp-exposure to ethylbenzene
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

The processes involved in the adaptation of animals to environmental factors such as chemicals have not yet been fully elucidated. We focused on the adaptive potential of the mouse liver against hepatotoxic chemical-induced injury.

Publication Title

No associated publication

Sample Metadata Fields

Age, Specimen part

View Samples
accession-icon GSE22534
Expression data from PDK4 overexpressing (Ad-PDK4 infected) and control (Ad-control infected) mouse liver
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

We identified PDK4 as a gene with adaptive transcriptional response to chemical stress. Although PDK4 is an energy resource regulator induced by starvation, expression of other fasting-inducible genes was unaffected, indicating additional physiological role of PDK4 for liver adaptation to the chemical stress.

Publication Title

Adaptive gene regulation of pyruvate dehydrogenase kinase isoenzyme 4 in hepatotoxic chemical-induced liver injury and its stimulatory potential for DNA repair and cell proliferation.

Sample Metadata Fields

Age, Specimen part

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accession-icon GSE35978
Expression data from the human cerebellum and parietal cortex brain
  • organism-icon Homo sapiens
  • sample-icon 233 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Two gene co-expression modules differentiate psychotics and controls.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

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accession-icon GSE35977
Expression data from the human parietal cortex brain
  • organism-icon Homo sapiens
  • sample-icon 123 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders. Associated genetic and gene expression

Publication Title

Two gene co-expression modules differentiate psychotics and controls.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

View Samples
accession-icon GSE35974
Expression data from the human cerebellum brain
  • organism-icon Homo sapiens
  • sample-icon 110 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders. Associated genetic and gene expression

Publication Title

Two gene co-expression modules differentiate psychotics and controls.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

View Samples
accession-icon GSE38662
Expression data from human embryonic stem cells(hESCs)
  • organism-icon Homo sapiens
  • sample-icon 68 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

To detect the effect of early culture on hESCs, almost all initial-passaged hESCs have normal expression of DLK1-DIO3 gene cluster, the low-passaged hESCs lost the expression of DLK1-DIO3 gene cluster.

Publication Title

Physiological oxygen prevents frequent silencing of the DLK1-DIO3 cluster during human embryonic stem cells culture.

Sample Metadata Fields

Sex, Specimen part, Cell line

View Samples
accession-icon GSE64634
mRNA expression profiling of nasopharyngeal carcinoma
  • organism-icon Homo sapiens
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Nasopharyngeal carcinoma is an Epstein-Barr virus-associated epithelial cancer with high prevalence in Southeast Asia. mRNA expression levels were measured for essentially all human genes in nasopharyngeal carcinoma tissue samples and normal nasopharyngeal tissues. Data were analyzed for differential gene expression between tumor and normal tissue.

Publication Title

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.

Sample Metadata Fields

Disease, Disease stage

View Samples
accession-icon GSE70772
Expression data from colon cancer cell HCT116 mouse xenograft - Control vs. traditional Chinese medicine Astragalus membranaceus-treated conditions
  • organism-icon Homo sapiens
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Transcriptome Array 2.0 (hta20)

Description

To identify biomarkers regulated by traditional Chinese medicine Astragalus membranaceus Fischer Bge. var. mongolicus Bge. Hsiao in colorectal cancer. We have identified several differentially expressed genes including microRNAs using Affymetrix HTA-2.0 array.

Publication Title

An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract.

Sample Metadata Fields

Specimen part

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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